This report by the Human Sciences Research Council (HSRC) covers the period 2012–2015. It provides an overview of the achievements of the Conrad N. Hilton Foundation’s initiative for children affected by HIV and AIDS, and points to areas where success has revealed additional challenges. Many of these challenges exist generally in the field, providing opportunities for the Foundation to take the lead in addressing them. In order to be fair to all funded partner organizations, no partners are named in the report. However, short summaries of the country and program activities of each of the 16 partners are available online.